Research Projects
We encourage health centers to engage in research and we are here to help them be successful. Beyond health centers, AllianceChicago collaborates in research with academic institutions, research institutions, foundations, other non-profits, and government agencies
Active Projects
Capacity Building
The gaps in translating research to practice are well-known and may be more pronounced in Community Health Center (CHCs), where opportunities for clinicians to benefit from access to and learning about contemporary evidence, research findings, and practice guidelines are fewer than in academic settings. The primary objective of E-REACH is to improve organizational capacity to disseminate PCORI-funded Patient-Centered Outcomes Research and Comparative Effectiveness Research findings to support CHC clinicians in understanding and responding to the chronic health needs of their patients. Funder: This project was funded thorugh a Patient-Centered Outcomes Research Institute (PCORI) Eugene Washington PCORI Engagement Award (EADI-30482).
NP3 and AllianceChicago are partnering together to foster a shared vision of enhancing research relationships between academic researchers and health centers within the AllianceChicago network and promoting practice-based research in health centers. This partnership makes it possible for AllianceChicago to dedicate resources towards prep-to-research and capacity building activities.
Young And A Survivor! (YAAS!) is a network of survivors, co-survivors, patient advocates, clinicians, support services providers, researchers, and local and national advocacy organizations working collaboratively to reduce disparities in survival and quality of life due to race, ethnicity, and other social determinants of health among young breast cancer survivors and metastatic breast cancer survivors in Chicago.
Chronic Disease Management
This study seeks to characterize key timing and drivers of maternal and child cardiovascular health from preconception through postpartum, to help direct resources and inform future pragmatic, person-centered interventions.
The Sharing TELE-CARE Learnings project (TELE-SHARE) aims to disseminate the results of a prior AllianceChicago study to FQHCs in Chicago and beyond with a focus on those organizations that contributed data to the analysis. We aim to facilitate discussions about how to translate the findings into meaningful change, as FQHC clinicians and staff are instrumental in sharing preferred practices among peers and in integrating evidence in clinical practice.
This pilot aims to test the accuracy of a natural language processing algorithm to identify patients with reduced ejection fraction (HFrEF) seen at Community Health Centers within the AllianceChicago network.
The purpose of the project is to expand a central repository of data available to diabetes researchers and collaborators in order to improve diabetes for adult patients in CHCs and to engage CHC clinicians and staff in training and other activities to catalyze diabetes research in their settings. Funder: NIH/NIDDKD
Cardiovascular health (CVH) starts very early in life and worsens with age. The overarching goal of this study is to identify CVH trajectories from birth through age 20 from 7,000 parents and their children in the Chicago area. Patients of Community Health Centers (CHCs) will be invited to participate in this study via text and email. Follow up surveys will be used to help define CVH metrics and create a tool to promote cardiovascular health. Funder: National Institutes of Health (NIH)
Multi-state EHR-based Network for Disease Surveillance (MENDS) is an EHR-based pilot chronic disease surveillance system led by the National Association of Chronic Disease Directors (NACDD) and funded by CDC Division for Heart Disease and Stroke Prevention, this project takes chronic disease data and uses weighting and modeling to display and analyze it via two software tools, RiskScape and PopMedNet. Riskscape visualizes the data into charts, figures, and maps to provide quality visuals that help inform work around chronic diseases. The key to this project is its usefulness in analyzing and transforming any healthcare data into visualizations that allow for comprehensive and meaningful views. Any data available in EHRs has the potential to be leveraged via the two tools in use by this project. At AllianceChicago, we have 18 health centers contributing data to this effort, with 6 from Illinois. This project has local partnerships with the Chicago Department of Public Health (CDPH) and with the Cook County Department of Public Health (CCDPH). Funder: CDC
The “Tipping Points” project studies how health coaches may affect the health and wellness of patients with multiple chronic diseases. The new health coaching program will augment regular medical care, including positive affect interventions designed to help patients set their own life goals. Funder: Patient-Centered Outcomes Research Institute (PCORI)
This project seeks to better characterize underrepresented populations living with type 1 diabetes and insulin-requiring diabetes seen for care at Federally Qualified Health Centers (FQHCs) and to identify barriers for Primary Care Providers delivering diabetes care to underserved communities within FQHCs. Funder: Helmsley Charitable Trust
Infectious Disease/COVID
With the profound disparities uncovered by the COVID-19 pandemic, compounded by the longstanding disparities in rheumatic disease outcomes, our overarching goal is to better understand and address low vaccine uptake and hesitancy among communities of Black individuals with these conditions. Framed by awareness of the role of structural racism, we will build upon our existing community-academic partnerships across two cities to develop and test a scalable intervention comparing two strategies to educate community leaders to change vaccine-related norms. Funder: National Institutes of Health (NIH)
The objective of this study is to implement strategies to increase uptake and support PrEP persistence among Black cisgender women in community health center (CHC) settings. AllianceChicago and Health Choice Network will partner with University of Chicago for this 5-year NIH-funded project. This study will take place at 12 locations of care within 3 CHCs, including 4 sites in the Midwest and 8 in the Southern U.S. Funder: NIH
The overarching goal of this project is to identify and apply best practices for strengthening childhood vaccination rates toward improving Human Papillomavirus (HPV) uptake for children and adolescents seen in Community Health Centers (CHCs) through implementation of a quality improvement-focused learning collaborative for CHC immunization champions. Funder: Merck Sharp & Dohme LLC
Communities served by FQHCs are more likely to be under-vaccinated and have poor health outcomes associated with vaccine preventable diseases. Multiple factors contribute to low vaccination rates in medically underserved populations including equitable vaccine distribution, provider behaviors, clinic workflow, and lack of vaccine confidence among patients. The goal of this observational cohort study is to address knowledge gaps in factors associated with vaccination completion and refusal of vaccines against human papillomavirus, influenza, COVID-19, and pneumococcus among patients served by FQHCs. Funder: Merck Sharp & Dohme LLC
Maternal Child Health
The HBCD study will examine healthy brain and behavioral development across the critical first years of life with a national, diverse sample of 7,500 women and children. The study will also monitor the development of children who have been exposed to substance use and other adversities during pregnancy across a 10-year period. Mothers and babies will complete several research visits each year that include surveys, infant developmental and behavioral assessments, neuroimaging, and biospecimen collection. Funder: National Institutes of Health (NIH)
Using an implementation science framework, we aim to understand how a two-generation model of postpartum care could be implemented in diverse clinical settings. To do this we propose to conduct qualitative interviews with clinicians and administrators from 10 clinical sites across the country. Funder: National Institute of Child Health and Human Development (NICHD)
iREACH aims to reduce peanut allergy risk through a clinical decision support (CDS) tool incorporated into participating health centers’ electronic health record. The CDS iREACH tool, developed and tested by pediatricians, is designed to support providers in identifying infants at high-risk for peanut allergy, testing or allergist referrals for infants, assessing risk of the results, and counseling parents of infants on introduction of peanut products. Funder: National Institutes of Health (NIH)
The overarching aim of this study is to determine the optimal patient-centered strategy to improve care for children with acute otitis media and reduce unnecessary antibiotic use to mitigate antibiotic-associated harms. Funder: Patient-Centered Outcomes Research Institute (PCORI)
The LINCC Trial is a co-scheduling intervention that links well-baby visits with postpartum contraceptive care in order to reduce rates of short interval pregnancy. Funder: National Institutes of Health (NIH)
OPTIMIZE aims to address inequity perinatal healthcare, particularly for African American women. The OPTIMIZE checklist is a strategy to facilitate coordination and integration of efforts to improve perinatal care for AA women. Aims 1. Develop the OPTIMIZE checklist with interviews and/or focus groups with AllianceChicago CHCs staff and patients 2. Conduct pragmatic, randomized trials in CHCs to evaluate the effectiveness and implementation of the OPTIMIZE checklist strategy 3. Conduct process evaluation, including conducting organizational surveys and interviews with clinic staff and patients. Funder: NIH
This study will test a technology-based strategy to promote preconception care and diabetes self-management among English and Spanish-speaking women with type 2 diabetes in primary care. Aims 1. Test the medication reconciliation (MedRec) tool and deliver low literacy print tools to support diabetes self-care as well as post-visit text messaging to encourage healthy lifestyle behaviors to eligible patients 2. Analyze EHR data (e.g., HbA1c, blood pressure) on enrolled participants 3. Request feedback (via brief electronic survey) from 10 CHC personnel on their experience with the project. Funder: NIH
STEP-UP aims to test the effectiveness and fidelity of a technology enabled, ‘stepped care’ strategy to connect high-risk, postpartum patients to primary care within community health care settings. Interventions will include the use of Clinical Decision Support that prompts counseling and referral of high-risk patients to primary care, the inclusion of health-literacy educational materials as part of after-visit summary and text message reminders to motivate patients to schedule and attend primary care visits. Funder: National Institutes of Health (NIH)
The Illinois Maternal Health Innovation (MHI) Program aims to 1) Maintain a State Maternal Health Task Force and draft a new five-year Maternal Health Strategic Plan; 2) Improve the State-Level Maternal Health Data and Surveillance; and, 3) Promote and Execute Innovation in Maternal Health Service Delivery.
Through the Maternal Health Research Center of Excellence, the University of Illinois Chicago and AllianceChicago will establish a new program to develop, train, and support community health center researchers to study maternal health.
Mental/Behavioral Health
Pediatrics
Practice Optimization
Previous work by AllianceChicago found FQHC compliance officers’ interpretations of how to apply regulations varied widely from one another, and misinterpretations of regulations were commonly held. This study will build on that work to further survey a broader sample to increase knowledge of appropriate application of regulations by compliance officers and teams in ambulatory settings throughout the U.S.
This project will study the adaptation and implementation of an evidence-based secure firearm storage program, S.A.F.E. Firearm, in community health center settings.
Social Determinants of Health
This study will examine the impact of structural and interpersonal racism on the development of suicidal thoughts and behavior (STB) among school-age Black children with ADHD, the impact of clinical and contextual protective factors on future STB, and parent and child-reported perspectives on and experiences with racism and STB.
Social impact
individuals are removed from the Medicaid program and are then required to re-apply. Funder: Robert Wood Johnson Foundation
Substance Use
The IMPACT project aims to support the implementation of a bidirectional eReferral tool to the Illinois Tobacco Quitline (ITQL) at one Community Health Center in Chicago. The eReferral system will target all smokers who have a primary care visit during the grant period who are deemed by the provider to be ready to make a quit attempt. The goal of the project is to increase the number of referrals to the ITQL, increase smoking cessation counseling, and ultimately increase smoking cessation rates. A secondary aim is to increase reach to patients with housing insecurity.